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I ended up having to go 9 days without it. If you think you may have a medical emergency, call your physician or 911 immediately I asked if they could get me a refill and they said no. Userdeletedalias63786577 Answer (1 of 11): How long can a body survive without thyroid hormones? Like someone else said, you can pay for a few days worth to get you through. In the study, 291 patients were asked to stop their levothyroxine/synthroid medication for 6-8 weeks. Anyone of them, all good You can't leave this situation. Synthroid (esp generic) isn’t very expensive. I'm concerned how serious this could effect me It can take a few days to a few weeks for you to even start noticing a difference in how you feel. You will also want to use the same brand. Org and it will tell you all of the systems it helps regulate. Votes: +2 LI Lizard71 4 Aug 2016. By using this Site you agree to the following Terms and Conditions. You should also make sure you have the medication level checked every 3 months, or whenever your doctor tells you to come back because you will likely have symptoms if the level is off either way. You Experience New or Worsening Symptoms. If you are truly hypothyroid, discontinuing your thyroid medication for a longer period of time can have serious consequences. If you don't feel better after taking your medication for several months, you may need a dose adjustment or a different medication—not a complete stop of your regimen. A few days you should be good but I wouldn’t wait too long. You can look up the thyroid in wikipedia. We offer this Site AS IS and without any warranties. I have had hypothyroidism for a while and can definitely feel the difference. The body can survive for many years without a thyroid gland. One study found that as many as 61% of thyroid patients may be unnecessarily taking thyroid medication. I called the pharmacy and got no answers from them either. I was in severe state heading into coma. Buy what you need for time being until you get your prescription filled.. Within a few days to weeks, you can expect symptoms of hypothyroidism, including: Fatigue Brain fog Depression and/or anxiety Constipation Dry skin and hair Hair loss Weight gain. Anyways to make a long story short, I had a total thyroidectomy and have been taking synthroid 100mcg (was just dropped down from 112mcg). It can take several weeks to determine if the amount is therapeutic or not. If someone were to have a total thyroidectomy ( removal of all the thyroid gland), it would take weeks or months for the levels of thyroid hor. I only managed 10 days without thyroxine. Once you find the right dose of thyroid medication, is it essential that you stay on that same dose and take it every day. It's imperative that you get thyroxine or liothyronine or natural desiccated Thyroid hormone. Many patients had been on this medication for years without exhibiting thyroid-related symptoms In contrast, others are started at low doses between 25mcg-50mcg/day and titrated up as necessary.